Optimization Methods in Metabolic Networks by Costas D. Maranas, Ali R. Zomorrodi

Optimization Methods in Metabolic Networks Costas D. Maranas, Ali R. Zomorrodi ebook
Format: pdf
ISBN: 9781119028499
Page: 232
Publisher: Wiley

Metaboflux : a method to analyze flux distribution in metabolic networks input parameters until the system reach the best optimization of the objective function. Fluxes in metabolic networks using non-linear dynamic optimization. Modeling metabolic networks in C. Constraint-Based Modeling of Metabolic Networks Catabolism and anabolism; The metabolic core – production of energy Outline: Optimization Methods. Expansion of metabolic networks and global reactome coverage over time. Mathematical optimization approaches, to assist in fundamental metabolic network analyses and redesign efforts. (Systems Optimization: Maximizing molar yields. The method presented here extends EFM analysis to genome-scale models. Metabolic network reconstruction and simulation allows for an in-depth insight into These semi-automatic methods allow for a fast draft to be created while using flux balance analysis, a single solution is found to the optimization problem . Optimization Methods in Metabolic Networks. Metabolic networks are complex due to their size and the These methods should be systemic. However, this method cannot be used for quantitative analysis of the metabolic network. Modularity is often used in optimization methods for detecting community structure in networks. Modularity is one measure of the structure of networks or graphs. When optimizing a metabolic network for a given objective two distinct problems must be addressed. Genome Scale Metabolic Modeling methods represent one way to compute whole include (1) reconstruction of a metabolic network from the genome sequence, (2) its to a model, and (4) the analysis using linear algebra and optimization. A review of the method can be seen in [7].